right,I think so.
for ecxample:
<frameset >
<frame >
<frameset>
<frame name="left" src="left.aspx">
<frame name="right" src="right.aspx">
</frameset>
</frameset>
when you click one buttom or link in left frame,you should write the below code in this buttom_click event.
Response.Write("window.parent.main.location='right.aspx';")